设为首页  |  加入收藏

 首页  关于我们  科研团队  研究方向  课题和成果  合作企业  实验室设备  新闻资讯  联系我们 
站内搜索:
课题和成果

 承担课题 
 发表文章 
 发明专利 
 成果和奖项 

发表文章
您的位置: 首页>>课题和成果>>发表文章
发表文章

1. Zhan Y, Zhou M, Wang H, Chen L, Li Z, Cai D, Wen Z, Ma X*, Chen S*, 2019, Efficient production of 2-phenylethanol from L-phenylalanine by engineered Bacillus licheniformis using molasses as carbon source, Appl. Microbiol. Biotechnol.

2. Cai D, Zhu J, Li Y, Li L, Zhang M, Wang Z, Yang H, Li J, Yang Z, Chen S*2020Systematic engineering of branch chain amino acid supply modules for the enhanced production of bacitracin from Bacillus licheniformis, Metabolic Engineering Communications, MEC_e00136

3. Wang D, Wang H, Zhan Y, Xu Y, Deng J, Chen J, Cai D, Wang Q, Sheng F*, Chen S*,2020, Engineering expression cassette of pgdS for efficient production of poly-γ-glutamic acids with specific molecular weights in Bacillus licheniformis, Front Bioeng Biotechnol,

4. Xiao J, Peng B, Su Z, Liu A, Hu Y, Nomura C, Chen S*, Wang Q*, 2020, Facilitating protein expression with portable 5’-UTR secondary structures in Bacillus licheniformis, ACS Synth Biol

5. Rao Y, Cai D, Wang H, Xu Y, Xiong S, Chen S*, Ma X*, 2020, Construction and application of the dual promoter system for protein efficient production and metabolic pathway enhancement in Bacillus licheniformis, J Biotechnol 312:1-10

6. Cai D, Zhang B, Zhu J, Xu H, Liu P, Wang Z, Li J, Yang Z*, Ma X, Chen S*2020Enhanced bacitracin production by systematically engineering S-adenosylmethionine supply modules in Bacillus licheniformis, Front Bioeng Biotechnol,

7. Wang S, Wang D*, Li X, Zhang D, Zhang J, Zhan Y, Cai D, Ma X, Chen S*, 2020, Efficient production of pulcherriminic acid in Bacillus licheniformis by multistep metabolic engineering, Appl. Environ Microb 03041-19. doi: 10.1128

8. Zhan Y, Xu Y, Zheng P, He M, Sun S, Wang D, Cai D, Ma X, Chen S*, 2020, Establishment and application of multiplexed CRISPR interference system in Bacillus licheniformis, Appl. Microbiol. Biotechnol. 104,1:391–403

9. Xu Y, Cai D, Zhang H, Gao L, Yang Y, Gao J, Li Y, Yang C, Z, Yu J*, Chen S*. 2019, Enhanced production of iturin A in Bacillus amyloliquefaciens and its effect on suppression of Alternaria alternate, Process Chem

10. Mo F, Cai D, He P, Yang F, Chen Y, Ma X*, Chen S*, 2019, Enhanced production of heterologous proteins via engineering the cell surface of Bacillus licheniformis, J Ind Microbiot Biot, 46,12 : 1745-1755

11. Wu F, Cai D*, Li L, Li Y, Yang H, Li J, Ma X, Chen S*, 2019, Modular metabolic engineering of lysine supply for enhanced production of bacitracin in Bacillus licheniformis, Appl. Microbiol. Biotechnol. , 103, 21-22: 8799-8812

12. Cai D, Zhang B, Rao Y, Li L, Zhu J, Li J, Ma X, Chen S*, 2019, Improving the utilization rate of soybean meal for efficient production of bacitracin and heterologous proteins in the aprA deficient strain of Bacillus licheniformis, Appl. Microbiol. Biotechnol. 103(120):4789-4799

13. Shi J, Zhan Y, Zhou M, He M, Wang Q, Li X, Wen Z, Chen S*, 2019, High-level production of short branched-chain fatty acids from waste materials by genetically modified Bacillus licheniformis, Bioresour Biotechnol. 271:325-331

14. Cai D, Zhu J, Zhu S, Lu Y, Zhang B, Lu K, Li J, Ma X, Chen S*, 2019, Metabolic engineering of main transcription factors in carbon, nitrogen and phosphorus metabolisms for enhanced production of bacitracin in Bacillus licheniformis, ACS Synth Biol, 19;8(4):866-875

15. Yuan H, Xu Y, Chen Y, Zhan Y, Wei X, Li L, Wang D, He P, Li S, Chen S*, 2019, Untargeted metabolomics analysis reveals global acetoin stress response of Bacillus licheniformis, Metabolomics, doi:10.1007/s11306-019-1492-7

16. He P, Wan N, Cai D, Hu S, Chen Y, Li S, Chen S*, 2019,13C-Metabolic Flux Analysis Reveals the Metabolic Flux Redistribution for High-level Production of Poly-γ-Glutamic acid in dlt over-expressed Bacillus licheniformis, Front Microbiol, fmicb.2019.00105

17. Qiu Y, Wang Q, Zhu C, Yang Q, Zhou S, Xiang Z, Chen S*, 2019, Deciphering metabolic responses of biosurfactant lichenysin on biosynthesis of poly-γ-glutamic acid, Appl. Microbiol. Biotechnol. 103(10), 4003-4015

18. Cai D, Rao Y, Zhan Y, Wang Q, Chen S*,2019, Engineering of Bacillus as the efficient host strain for heterologous protein production: current progress, challenge and prospectJ Appl Microbiol 126, 1632--1642

19. Yang L, Yuan H, Yang Y, Wang R, Wang C, Wei X, Chen S, Yu J*, Ma X*, 2019, Enhanced lignin degradation in tobacco stalk composting with inoculation of white-rot fungi Trametes hirsuta and Pleurotus ostreatus, Waste Biomass Valorization

20. Yu W, Li D, Jia S, Liu Z, Nomura CT, Li J, Chen S, Wang Q, 2019, Systematic metabolic pathway modification to boost l-ornithine supply for bacitracin production in Bacillus licheniformis DW2, Appl. Microbiol. Biotechnol.103,20: 8383-8392

21. Liu Z, Yu W, Nomura CT, Li J, Chen S, Yang Y*, Wang Q*, 2018, Increased flux through the TCA cycle enhances bacitracin production by Bacillus licheniformis DW2. Appl Microb Biotechnol 102(16): 6935–6946

22. Li LRuan L, Ji A, Wen Z, Chen S, Wang L, Wei X, 2018Biogenic amines analysis and microbial contribution in traditional fermented food of DouchiScientific Reports 8(1)DOI:10.1038/s41598-018-30456-z

23. Zhu S, Cai D, Liu Z, Zhang B, Li J, Chen S*, Ma X*,2018, Enhanced production of Bacitracin by NADPH generation overexpressing glucose-6-phosphate dehydrogenase Zwf in Bacillus licheniformis, Appl Biochem Biotechnol. 187(4), 1502-1514

24. Zhan Y, Sheng B, Wang H, Shi J, Cai D, Yi L, Yang S, Wen Z, Ma X, Chen S*,2018, Rewiring glycerol metabolism for enhanced production of poly-γ-glutamic acid in Bacillus licheniformis, Biotechnol Biofuels 11:306

25. Zhu J, Cai D, Xu H, Liu W, Zhang B, Wu F, Li J, Chen S*, 2018, Enhancement of precursor amino acid supplies for improving bacitracin production by activation of branched chain amino acid transporter BrnQ and deletion of its regulator gene lrp in Bacillus licheniformis, Synth Syst Biotechnol 3: 235-243

26. Li B, Cai D, Hu S, Zhu A, He Z, Chen S*, 2018, Enhanced synthesis of poly gamma glutamic acid by increasing the intracellular reactive oxygen species in the Δ1-pyrroline-5-carboxylate dehydrogenase gene ycgN deficient strain of Bacillus licheniformis, Appl. Microbiol. Biotechnol. 102(23), 10127-10137

27. Chen Y, Cai D, He P, Mo F, Zhang Q, Ma X, Chen S*, 2018, Enhanced production of heterologous proteins by Bacillus licheniformis with defective D-alanylation of teichoic acid, World J Microbial Biotechnol, 9:135

28. Cai D, Chen Y, He P, Wang S, Mo F, Li X, Wang Q, Nomura CT, Wen Z, Ma X*, Chen S*. 2018, Enhanced production of Poly-γ-glutamic acid by improving ATP supply in metabolically engineered Bacillus licheniformis, Biotechnol Bioeng, 10:2541-2553

29. Wang D, Zhan Y, Li X, Cai D, Wang Q, Chen S*, 2018, Regulation of the Synthesis and Secretion of the Iron Chelator Cyclodipeptide Pulcherriminic Acid in Bacillus licheniformis, Appl. Environ Microb. 84(13) : 00262-18

30. Wu B, Liu F, Weiser M, Ning D, Shen L, Li J, Deng Y, Wu L, Chen S*, Zhou J*, He Z*, 2018, The diversity and biogeography of N2O-reducing microbial communities in forest soils along a temperature gradient, Funct Ecol. 7:1867-1878

31. Li K, Cai D, Wang Z, He Z, Chen S*, 2018, Development of an Efficient Genome Editing Toolkit in Bacillus licheniformis Using CRISPR-Cas9 Nickase, Appl. Environ Microb., 84(6):02608-17

32. Zuo S, Hiao J, Zhang R, Zhang X, Nomura C, Chen S*, Wang Q*, 2018, Rational design and medium optimization for shikimate production in recombinant Bacillus licheniformis strains, Process Biochem. 6619-27

33. Cai D, Hu S, Chen Y, Wang H, Li L, Ma X*, Chen S*, 2018, A novel strategy to improve the γ-PGA production by overexpression of global anaerobic regulator Fnr in B. licheniformis WX-02, Appl. Biochem. Biotechnol.4:985-970

34. Huo Y, Zhan Y, Wang Q, Li S, Nomura CT, Yan S, Wang C*, Chen S*, 2017, Acetolactate Synthase from Bacillus licheniformis is an Efficient for Acetoin/Butanediol and L-Valine Biosynthesis, Bioprocess and Biosyst Eng, 41(1):87-96

35. Wang D, Wang Q, Qiu Y, Nomura CT, Li J, Chen S*, 2017, Untangling the transcription regulatory network of the bacitracin synthase operon in Bacillus licheniformis DW2, Res Microbiol, 168: 515-523

36. Zhu C, Xiao F, Qiu Y, Wang Q, He Z*, Chen S*,2017Lichenysin production is improved in codY knocked-out Bacillus licheniformis by addition of precursor amino acids, Appl. Microbiol. Biotechnol.101:6375-6383

37. Zhan Y, Zhu C, Sheng B, Wen Z, Chen S*, 2017, Improvement of glycerol catabolism in Bacillus licheniformis for production of poly-γ-glutamic acid, Appl. Microbiol. Biotechnol. 101: 7155–7164

38. Li X, Wang D, Zhan Y, Cai D, Chen S*, 2017, Identification and High-level Production of Pulcherrimin in Bacillus licheniformis DW2, Appl. Biochem. Biotechnol. 183(4), 1323-1335,

39. He P, Cai D, Chen Y, Wang H, Li S, Chen S*,2017, High-level production of α-amylase by manipulating the expression levels of Alanine racamase in a food-grade expression system in Bacillus licheniformis, Biotechnol. Lett. 39(9):1389-1394

40. Wang Q, Zheng H, Ji Z, Li J, Wang C*, Chen S*, 2017, Optimization of inexpensive agricultural byproducts as raw materials for bacitracin production in Bacillus licheniformis DW2, Appl. Biochem. Biotechnol.183(4):1146-1157

41. Cai D, Wang H, He P, Zhu C, Wang Q, Wei X, Nomura CT, Chen S* , 2017, A Novel Strategy to Improve Protein Secretion via Over-expression of Signal Peptide Peptidase SppA in Bacillus licheniformis, Microbial Cell Fact,16:70

42. Li L, Zhang J, Wei X, Wen Z*, Chen S*, 2017, Enhancement of acetoin production from Bacillus licheniformis by 2,3-butanediol conversion strategy: metabolic engineering and fermentation control, Process Biochem,57:35-42.

43. Cai D, Zhu C, Chen S*, 2017, Microbial production of Nattokinase: current progress, challenge and prospect, World J Microbiol Biotechnol, 33(5):84.

44. Tian G, Wang Q, Wei X, Ma X, Chen S*, 2017, Glutamate dehydrogenase ( RocG ) plays a key role in glutamate synthesis for Poly-γ-glutamic acid production in Bacillus licheniformis WX-02, Enzyme Microb. Technol., 99:9-15

45. Cai D, He P, Lu X, Zhu C, Zhu J, Zhan Y, Wang Q, Wen ZChen S*, 2017, A novel approach to improve poly-γ-glutamic acid production by NADPH Regeneration in Bacillus licheniformis WX-02Sci. Rep, 7: 43404

46. Cai D, Liu M , Wei X, Li X, Wang Q, Nomura CT, Chen S*, 2017,Use of B. amyloliquefaciens HZ-12 for high-level production of the blood glucose lowering compound, 1-deoxynojirimycin (DNJ), and nutraceutical enriched soybeans via fermentation, Appl. Biochem. Biotechnol., 181:1108–1122

47. Chen Y, Liu M, Chen S, Wei X, 2017, Decreased formation of branched-chain short fatty acids in Bacillus amyloliquefaciens by metabolic engineering, Biotechnol Lett, 39:529-533

48. Qiu Y, Zhang J, Li L, Wen Z, Nomura CT, Wu S*, Chen S*, 2016, Engineering Bacillus licheniformis for the production of meso-2,3-butanediol, Biotechnol. Biofeul,9:117

49. Wu B, Wang X, Yang L, Yang H, Zeng H, Qiu Y, Wang C, Yu J, Li J, Xu D, He Z*, Chen S*, 2016, Effects of Bacillus amyloliquefaciens ZM9 on bacterial wilt and rhizosphere microbial communities of tobaccoApplied Soil Ecology,103:1-12 ,

50. Wang J, Yuan H, Wei X, Chen J, Chen S*, 2016Enhancement of poly-γ-glutamic acid production by alkaline pH stress treatment in Bacillus licheniformis WX-02, J. Chem. Technol. Biotechnol 91:2399 -2403

51. Cai D, Wei X, Qiu Y, Chen Y, Chen J, Wen Z, Chen S*, 2016, High-level Expression of nattokinase inBacillus licheniformis by manipulating signal peptide and signal peptidase, J. Appl Microbiol,121704–712

52. Gu W, Chen S, Chen G, Ji Z2015Enhancement of Haemophilus parasuis serovar 5 yields by medium optimizationLett Appl Microbiol

53. Li M, Chen S, Li J, Ji Z.2014, Propanol Addition Improves Natamycin Biosynthesis of Streptomyces natalensis. Appl Biochem Biotechnol, 172( 7):3424-3432.

54. Liang C, Huo Y, Qi G, Wei X, Wang Q, Chen S*, 2015, Enhancement of L-valine production in Bacillus licheniformis by blocking three br anched pathways, Biotechnol. Lett. 37: 1243-1248

55. Guo J, Cheng G, Gou X, Xing F, Li S, Han Y, Wang L, Song J, Shu C, Chen S*, Chen L*. 2015, Comprehensive transcriptome and improved genome annotation of Bacillus licheniformis WX-02, FEBS Lett, 589:2372-2381.  

56. Wei X, Zhou Y, Chen J, Cai D, Wang D, Qi G, Chen S*, 2015, Efficient expression of nattokinase in Bacillus licheniformis: host strain construction and signal peptide optimization, J Ind. Microbiol. Biotechnol., . 42:287-295

57. Wei X, Tian G; Ji Z, Chen S*, 2015, A new strategy for enhancement of poly-γ-glutamic acid by multiple physicochemical stresses in Bacillus licheniformis, J. Chem. Technol. Biotechnol. 90:709-713

58. Yuan H, Wei X, Zeng Z, Yang D, Chen S*, 2014, Poly-γ-glutamic acid modified magnetic nanoparticles for fast solid phase extraction of trace amounts of Cu (II) and Pb (II), Analytical Methods,  196:9800–9806

59. Wei X, Deng X, Ji Z, Wang C, Yu J, Li J, Chen S*, 2014,Decreased Tobacco-specific Nitrosamines by Microbial Treatment with Bacillus amyloliquefaciens DA9 during Air-curing Process of Burley Tobacco, J. Agri. Food Chem., 62:12701–12706

60. Qi G, Kang Y, Li L, Xiao A, Zhang S, Wen Z, Xu D, Chen S*, 2014, Deletion of meso-2,3-butanediol Dehydrogenase Gene budC for Enhanced D-2, 3- butanediol Production in Bacillus licheniformis, Biotechnol. Biofeul, 7:16

61. Li X, Gou X, Long D, Ji Z, Hu L, Xu D, Liu J, Chen S*,2014, Physiological and Metabolic Analysis of Nitrate Reduction on Poly-gamma-Glutamic Acid Synthesis in Bacillus licheniformis WX-02, Arch Microb. 196:791-799.

62. Qiu Y., Xiao F., Wei X, Wen Z. Chen S*., 2014, Improvement of lichenysin production in Bacillus licheniformis by replacement of native promoter of lichenysin gene cluster, Appl. Microbiol. Biotechnol. 98:8895-8903.

63. Tian G, Fu J, Wei X, Ji, Z,  Ma X,  Qi G,  Chen S*, 2014, Enhanced expression of  pgdS gene for high production of poly-γ-glutamic aicd with lower molecular weight in Bacillus licheniformis WX-02, J. Chem. Technol. Biotechnol  89:1825-1832

64. Li X, Long D, Ji J, Yang W, Zeng Z, Guo S, Ji Z, Qi G, Chen S*, 2013, Sample preparation for the metabolomics investigation of poly-gamma-glutamate-producing Bacillus licheniformis by GC-MS, J Microbiol Method, 94:61-67

65. Zhou J, Xu Z, Chen S*, 2013, Simulation and prediction of the thuringiensin abiotic degradation processes in aqueous solution by a radius basis function neural network model, Chemosphere, 91:442-447

66. Yang W, Zhou Y, Lei Y, Qiu Y, Wei X, Ji Z, Qi G, Yong Y, Chen L, Chen S*,2012, Genome Sequence of Bacillus licheniformis WX-02, J. Bacteriol. 194:3561-3562

67. Yao D, Ji Z, Wang C, Qi G, Zhang Z, Ma X, Chen S*, 2012, Co-producing iturin A and poly-γ-glutamic acid from rapeseed meal under solid state fermentation by the newly isolated Bacillus subtilis strain 3-10, World J Microbiol Biotechnol, 28:985-991

68. Jiang F, Qi G, Ji Z, Zhang S, Liu J, Ma X, Chen S*, 2011. Expression of glr gene encoding glutamate racemase in Bacillus licheniformis WX-02 and its regulatory effects on synthesis of poly-γ-glutamic acid. Biotechnol Lett, 33(9):1837-1840

69. Liu Y, Zhang S, Yong Y, Ji Z, Ma X, Xu Z, Chen S*, 2011,Efficient production of acetoin by the newly isolated Bacillus licheniformis strain MEL09, Process Biochem., 46:390-394

70. Wei X, Ji Z, Chen S*, 2010, Isolation of halotolerant Bacillus licheniformis WX-02 and regulatory effects of sodium chloride on yield and molecular sizes of poly-γ-glutamic acid, Appl. Biochem. Biotechnol., 160: 1332-1340

71. Zhang X, Liang Z, Siddiqui Z, Gong Y, Yu Z, Chen S*, 2009, Efficient screening and breeding of Bacillus thuringiensis subsp. kurstaki for high toxicity against Spodoptera exigua and Heliothis armigera, J Ind. Microbiol. Biotechnol., 36:815-820.

72.Zhou J, Chang Y, Xu Z, Yu Z, Chen S*, 2007, Production of thuringiensin by fed-batch culture of Bacillus thuringiensis subsp. darmstadiensis 032 with an improved pH-control glucose feeding strategyProcess Biochem., 42:52-56.

73.Xu J, Chen S*, Yu Z2005, Optimization of process parameters for poly γ-glutamate production under solid state fermentation from Bacillus subtilis CCTCC202048, Process Biochem., 40:3075-3081.


湖北大学微生物工程研究室  地址:湖北省武汉市武昌区友谊大道368号
邮编:430062